Articles and Abstracts

Meleg-Smith S, Magliato S, Cheles RM, Garola E, Kashtan CEX-linked Alport syndrome in females.

Meloni I, Vitelli F, Pucci L, Lowry B, Tonlorenzi R, Rossi E, Ventura M, Rizzoni G, Kashtan CE, Pober B, Renieri A. Alport syndrome and mental retardation: clinical and genetic dissection of the contiguous gene deletion syndrome in Xq22.3 (ATS-MR). J Med Genet 39:359-365, 2002.
Cox ML, Lees GE, Kashtan CE, Murphy KE. Genetic cause of X-linked Alport syndrome in a family of domestic dogs. Mam Genome 14:396-403, 2003.
Merchant SN, Burgess BJ, Adams JC, Kashtan CE, Gregory MC, Santi PA, Colvin R, Collins B, Nadol JB.Temporal bone histology in Alport syndrome. Laryngoscope 114:1609-1618, 2004.
Rheault MN, Kren SM, Thielen BK, Mesa HA, Crosson JT, Thomas W, Sado Y, Kashtan CE, Segal Y.Mouse model of X-linked Alport syndrome. J Am Soc Nephrol 15:1466-1474, 2004.
Zehnder AF, Adams JC, Santi PA, Kristiansen AG, Wacharasindhu C, Mann S, Kalluri R, Gregory MC, Kashtan CE, Merchant SN. Distribution of type IV collagen in the cochlea in Alport syndrome. Arch Otolaryngol, 131:1007-1013, 2005.
Davidson A, Bell R, Lees G, Kashtan C, Davidson G, Murphy K. Genetic cause of autosomal recessive hereditary nephropathy in English cocker spaniels. J Vet Int Med 21:391-401.
Kashtan CEFamilial hematurias: what we know and what we don't. Pediatr Nephrol 20:1027-1035, 2005.
Kashtan CERenal transplantation in patients with Alport syndrome. Pediatric Transpl 2006:10:651-657, 2006.

Kashtan CEAlport syndrome and the X chromosome: implications of a diagnosis of Alport syndrome in females. Nephrology Dialysis Transplant: 22:1499-1505, 2007.
Kashtan, CE. (updated January 2008) Collagen IV-Related Nephropathies (Alport Syndrome and Thin Basement Membrane Nephropathy) in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle. 1997-2008. Available at
Kashtan, CE.  Familial hematurias (teaching article).  Pediatr Nephrol, Oct. 2, 2007 (epub ahead of print).
Kashtan, CE.  The wages of thin (Invited editorial). J Amer Soc Nephrol 18:2800-2802, 2007.
Gross O, Borza D, Anders H, Licht C, Weber M, Segerer S, Torra R, Gubler M, Heidet L, Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson D, Antignac C, Tryggvason K, Hudson B, Miner J.  Stem cell therapy for Alport syndrome: the hope beyond the hype.  Nephrol Dial Transpl, March 2009; 24: 731 - 734.
Kashtan CE.  Women with Alport syndrome:  risks and rewards of kidney donation (invited editorial).  Nephrol Dial Transpl 24:1369-1370, 2009.
Gross, Oliver and Kashtan, CliffordTreatment of Alport syndrome: beyond animal models. Kidney International advance online publication, 17 June 2009; doc10.1038/2009.
Rheault, Michelle, Kren, Stefan, Hartich, Linda, Wall, Melanie, Thomas, William, Mesa, Hector, Avner, Philip, Lees, George, Kashtan, Clifford, and Segal, Yoav. X-inactivation modifies disease severity in female carriers of murine X-linked Alport syndrome. Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp551, 2009. 

Vinge L, Lees GE, Nielsen R, Kashtan CE, Bahr A, Christenson E. The effect of progressive glomerular disease on megalin-mediated endocytosis in kidney. Nephrol Dial Transplant. 25:2458-67, 2010. 

Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching R, Wieslander J, Kashtan C, Borza D, Neilson E, Wilson CB, Hudson BG. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N Engl J Med. 363:343-54, 2010. 

Kashtan CE, Segal Y, Flinter F, Makanjuola D, Gan J, Watnick T. Aortic abnormalities in males with Alport syndrome. Nephrol Dial Transplant. 25:3554-60, 2010.

Kashtan CE, Ding J, Gregory M, Gross O, Heidet L, Knebelmann B, Rheault M, Licht C. Clinical practice recommendations for the treatment of Alport syndrome.  Pediatr Nephrol 28:5-11, 2013 PMID: 22461141

Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F.  Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy.  J Am Soc Nephrol 24:364-375, 2013  PMID: 2334931

Olaru F, Luo W, Wang XP, Ge L, Hertz JM, Kashtan CE, Sado Y, Segal Y, Hudson BG, Borza DB. Quaternary epitopes of a345(IV) collagen initiate Alport post-transplant anti-glomerular basement membrane nephritis, J Am Soc Nephrol 24:889-895, 2013 PMID: 23620401

Kashtan C, Segal Y.  Genetics of glomerular basement membrane diseases. Nephron Clin Pract, 118:c9-c18, 2011.  PMID: 21071975

Kashtan C.  Long-term management of Alport syndrome in pediatric patients.  Pediatr Health,  Medicine and Therapeautics 2013, i4:29-39

Miner JH, Baigent C, Flinter F, Gross O, Judge P, Kashtan CE, Lagas S, Savige J, Blatt D, Ding J, Gale DP, Midgely JP, Povey S, Prunotto M, Renault D, Skelding J, Turner NA, Gear S.  The 2014 International Workshop on Alport Syndrome.  Kidney Int doi:10.1038/ki.2014.229:

Kashtan CE. Genetics and biological therapies for Alport syndrome.  Expert Opinion on Orphan Drugs,

Rheault MN, Kashtan CE. Alport syndrome and thin basement membrane nephropathy.  In, Kher K, Greenbaum L, Schnaper W (Eds), Clinical Pediatric Nephrology, 3rd ed., in press

Rheault MN, Kashtan CE. Alport syndrome and thin basement membrane nephropathy.  In, Geary D, Schaefer F (Eds), Pediatric Kidney Disease, 2d ed., in press.

Speaking Engagements

Children's Hospital National Medical Center, Washington, D.C.  Visiting Professor.  April 15, 2010.

Alport Syndrome, A Symposium for Physicians, Researchers and Families, 15th Congress of the International Pediatric Nephrology Association, New York, NY.  Moderator and Speaker. August 28, 2010.
American Society of Nephrology Annual Meeting (Renal Week), Denver, CO.  Distinguished Faculty, In-Depth Nephrology Course:  Hereditary Nephritis and Thin Basement Membrane Nephropathy. November 16, 2010.
American Society of Nephrology Annual Meeting (Renal Week), Philadelphia, PA.  Distinguished Faculty, In-Depth Nephrology Course:  Collagen IV Glomerulopathies.  November 8, 2011

Alport Syndrome Family Conference, University of Minnesota.  Organizer, moderator and speaker.  July 21-22, 2012

Peking University First Hospital, Beijing, PR China.  Visiting Professor and Lecturer (“Familial Hematuria”).  November 30, 2012

First Parent Conference of Chinese Alport Syndrome, Peking University First Hospital, Beijing, PR China.  Invited speaker (“Alport Syndrome: An Overview”).  December 1, 2012

American Society of Nephrology Annual Meeting, Atlanta, GA.  Invited speaker on “Alport Syndrome – A Role for Early Identification and Intervention” in session entitled “When Glomerular Diseases Begin in Childhood.”  November 9, 2013

Prevention Genetics, Marshfield, WI.  Invited speaker (with Michelle Rheault):  Alport syndrome: a role for early identification and treatment.  September 8, 2014

American Society of Nephrology Annual Meeting (Kidney Week), Philadelphia, PA. Invited speaker, Human Genetics in Nephrology: Clinical Fundamentals and Research Advances Pre-course – “Alport syndrome and Thin Basement Membrane Nephropathy.” November 12, 2014

Pediatric Academic Societies/American Society of Pediatric Nephrology, San Diego, CA.  Invited speaker, Update in Glomerulonephritis 2015:  “Hereditary Nephritis.”  May, 2015


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